Pharmaceutical Industry Case

Pharmaceutical Industry Case

Project Date
October 2025
Location
China
Industry
Pharmaceutical Manufacturing
Client
A large API manufacturer
500
m³/h Capacity
0.5
mbar Vacuum
37
kW Power
2
Units Deployed

Project Background

This client is a leading API manufacturer in East China, with an annual production capacity exceeding 3,000 tons. Its main products include high-value-added APIs such as antibiotics and cardiovascular drugs. With increasingly stringent environmental regulations and increasing market demands for product purity, the client’s existing liquid ring vacuum system faced numerous challenges.

Main Issues Faced by the Customer:

  • The liquid ring vacuum pump consumes over 500,000 tons of circulating water annually, resulting in high operating costs.
  • The working fluid (water) comes into contact with solvent vapor, posing a risk of cross-contamination and impacting API purity.
  • Frequent maintenance leads to extended production line downtime, impacting capacity utilization.
  • Energy consumption reaches as high as 220kW, with electricity costs accounting for 18% of production costs.
  • Wastewater treatment pressure is high, and environmental compliance costs are rising.

The customer sought a technology upgrade to achieve a zero-pollution, low-energy, and highly reliable solvent recovery system that would meet the stringent FDA and EU GMP certification requirements.

Project Gallery

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Special Requirements

- 100% oil-free design, preventing any oil vapor contamination of API products - Suitable for mixed vapor environments with various organic solvents (methanol, ethanol, acetone, dichloromethane, etc.) - Compliant with ATEX explosion-proof standards, suitable for Zone 2 explosion-proof locations - Provides complete FDA DMF documentation and material certification - Remote monitoring interface supports integration with plant DCS systems - Continuous operation capability ≥ 8,000 hours/year, with planned maintenance downtime ≤ 24 hours/year

Our Solution

Based on the customer’s process flow and vacuum requirements, we recommended a dual-unit SDHV-200 dry screw vacuum pump solution. This solution offers the following key advantages:

System Configuration

  • Main Pump Configuration: Two SDHV-200 dry screw vacuum pumps, one in active mode and one in standby mode, ensuring continuous production.
  • Pre-condensation System: Three-stage condenser (+5°C / -10°C / -40°C), solvent recovery rate >98%
  • Automatic Control System:PLC + touch screen, enabling unmanned automatic switching
  • Safety Protection: Nitrogen protection, emergency pressure relief, and multiple temperature/pressure monitoring

Technical Innovations

Utilizing Shichang’s unique variable-pitch screw technology and intelligent temperature control system, the rotor temperature (80-150°C) can be automatically adjusted when processing high-boiling-point solvents, preventing corrosion and seizure caused by solvent condensation on the screw surface. The patented anti-corrosion-coated rotor is also suitable for use in strong acid and alkaline environments.

Implementation Period

The project took only 45 days from concept finalization to system commissioning, including the entire process of dismantling the old equipment, installing the new system, renovating the piping, integrating the DCS, and performing performance verification, minimizing disruption to production.

Project Video

Key Technical Highlights

1

Zero liquid pollution design

Completely dry operation, requiring no operating fluid, fundamentally eliminates the risk of cross-contamination of API products by water or oil. The rotor and cylinder utilize a micro-gap, non-contact design to ensure absolute cleanliness of the vacuum chamber, meeting the stringent requirements of FDA 21 CFR Part 211.

2

Intelligent frequency conversion energy-saving technology

Equipped with a Siemens frequency converter, the system automatically adjusts the speed (500-3000 rpm) based on the actual process load, saving 30-40% energy compared to constant speed operation. The system is equipped with an energy consumption monitoring module that displays real-time kWh/kg product energy consumption indicators to help customers optimize process parameters.

3

Predictive maintenance systems

Integrated IoT sensors monitor over 20 parameters, including bearing temperature, vibration, and current, 24 hours a day. AI algorithms provide 14-day advance warning of potential failures. Cloud-based data analysis optimizes maintenance plans, reducing unplanned downtime by 85% and lowering maintenance costs by 40%.

Project Results & Impact

Since its commissioning in June 2024, the system has operated stably for over 3,000 hours with zero downtime. Comparing operational data before and after the retrofit, the project has achieved significant economic and environmental benefits:

Economic Benefits

  • Annual electricity cost savings: Approximately 850,000 yuan (based on an industrial electricity price of 0.65 yuan/kWh)
  • Reduced water costs: Approximately 120,000 yuan/year (no need for circulating cooling water)
  • Reduced maintenance costs: Approximately 180,000 yuan/year (maintenance intervals extended from 500 hours to 8,000 hours)
  • Increased production capacity: Reduced downtime is equivalent to increased effective production. Production time: 240 hours/year
  • Static payback period: Only 14 months

Environmental Benefits

  • Reduced wastewater discharge by 50,000 tons annually, significantly reducing wastewater treatment pressure
  • Solvent recovery rate increased to 98.5%, recovering approximately 15 tons of additional organic solvents annually
  • Carbon emissions reduced by approximately 420 tons of CO₂ equivalent/year

Quality Improvement

API product purity increased from 99.2% to 99.7%, and the first-pass inspection pass rate increased from 92% to 99.5%, significantly enhancing product market competitiveness. The system has passed FDA surprise audits and EU GMP certification, laying the foundation for customers to expand into international markets.

Product Series

SDHV Series (Dry Screw Vacuum Pump)
Model Number
SDHV-200 × 2 units (1 for use and 1 for backup)

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Technical Specifications

Cooling method Closed-loop water cooling
Noise level ≤72 dB(A)
Operating temperature range -10 ~ 45 °C
Explosion-proof grade ATEX Zone 2
Equipment weight 1850 kg
Floor space 3.2 × 1.8 m

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